Figure 1 of
Houdart, Mol Vis 2005;
11:1061-1070.Figure 1 of
Houdart, Mol Vis 2005;
11:1061-1070.
Figure 1. In silico identification of putative PDE6γ-associating proteins
FBP17 SH3 domain was used as a query in the NCBI Conserved Domain Database program (CDD). The five closest neighbors identified by this procedure are shown. The GenBank accession numbers of the sequences are: NM_030846 for Grb2, D64045 for P85-PI3K, AF193494 for PACSIN, AL133293 for Src, and Y13380 for AMPHIPHYSIN. Residues in red match the FBP17 structure exactly.
TA RALYDFEGQAEDDLSFKXGDIL Majority
______________________________
10 20 30
1 PAIGTCK ALYTFEGQNEGTISVVEGETL FBP17
1 IAK YDFKATADDELSFKRGDIL Grb2
1 EG YQYRALYDYKKEREEDIDLHLGDIL P85-PI3K
1 TSGTEVRVRALYDYEGQEHDELSFKAGDEL Pacsin
1 TT FVALYDYESRTETDLSFKKGERL Src
1 R LDLPPGFMFKVQAQHDYTATDTDEL Amphiphysin
TVIEGD EDDGWLKG Majority
______________________________
40 50 60
29 SVIEED KGDGWTRI FBP17
23 KVLNEE CDQNWYKA Grb2
28 TVNKGSLV ALGFSDGQEARPEDIGWLNGY P85-PI3K
31 TKIEDE DEQGWCKG Pacsin
26 QIVNNT EGDWWLAH Src
27 QLKAGDVVLVIPFQNPEE QDEGWLMGV Amphiphysin
RLSTGEX GYIPXNYVEXI Majority
______________________________
70 80 90
43 RRNEDEE GYVPTSYVEVYLDKN FBP17
37 ELN GKD GFIPKNYIEMK Grb2
57 NETTGER GDFPGTYVEYI P85-PI3K
45 RLDSGQV GLYPANYVEAI Pacsin
40 SLSTGQT GYIPSNYVAPF Src
54 KESDWNQHKELEKCRGVFPENFTE Amphiphysin
Q Majority
____
65 AKGS FBP17
54 P Grb2
75 G P85-PI3K
63 Q Pacsin
57 Src
78 RVQ Amphiphysin
|