Table 3. Association of the 453*Serine variant with decreased cup/disk ratio

Three representative CYP1B1 SNPs, including 2805T>C, L432V and N453S, were selected and an effect of their minor alleles (first column) on the cup/disk ratio (CDR) was assessed by logistic regression. The second and third columns indicate the frequencies (and the corresponding percentages) of cases with a CDR less than or equal to 0.8 (column 2; 129 cases) and >0.8 (column 3; 68 cases). The fourth and fifth column report the estimates of odds ratios (OR) with 95% confidence intervals (95% CI) and the p values for each allele. The overall p value for the logistic model including the 3 alleles, adjusted for the time period between the diagnosis and the examination, was 0.0016. The data show that the 453*Serine allele is associated with a significantly decreased cupping of the optic disk.

Allele    CDR<=0.8     CDR>0.8      OR (95% CI)      p value
-------   ---------   ---------   ----------------   -------
2805*T    58 (45)     27 (39.7)   0.55 (0.28-1.1)    0.09
432*Val   87 (67.4)   53 (77.9)   1.04 (0.47-2.28)   0.93
453*Ser   60 (46.5)   16 (23.5)   0.32 (0.15-0.70)   0.0036