Figure 5 of
Otteson, Mol Vis 2005;
11:986-995.Figure 5 of
Otteson, Mol Vis 2005;
11:986-995.
Figure 5. Alignment of exon 1 from zebrafish crx with exons 1 and 2 from mammalian CRX identifies two regions of sequence similarity
Exon 1 of zebrafish crx contains regions of sequence similarity with both exons 1 and 2 of the mammalian CRX genes. The highest sequence identity is in the coding region and flanking 5' untranslated regions of exon1 in zebrafish crx and exon 2 in mammalian crx. There is a second region of sequence similarity between the 5' UTR of the zebrafish and exon 1 of the mammalian crx genes. The translation start site (ATG) is indicated by the three astericks (***) and identical bases are shown in blue. The following sequences were used in this alignment: Zebrafish (Danio rerio; AF503443) human (Homo sapiens; BC016664, BG396702); mouse (Mus musculus; AK053533); and dog (Canis familiaris; AF454668).
zebrafish EXON 1 (1) CGGCACGAGGCTCATAGTGTCCCGCTCCTGTCCGGTCTTACCCAAGG-GA
human EXON 1 (1) -------------------TGCCAC-CTTGGCCGGGATTACCCTCCGAGT
mouse EXON 1 (1) --------------------------------------------------
dog EXON 1 (1) --------------------------------------------------
zebrafish EXON 1 (50) CACGCGCCTTTACCAACGCCAAAACTCTGACCAAGAGCCAGCAACTTTTC
human EXON 1 (31) TCCAGGCCATGACAAATGACATCACTC---CC--GGCCCAGAAAATCTCC
mouse EXON 1 (1) --------------------------------------------------
dog EXON 1 (1) --------------------------------------------------
zebrafish EXON 1 (100) TCGCATATAGACATTTATTTGTTCTTTAACTCACAT-TAGGGTCTATTA
human EXON 1 (76) CCATGTGAGGGGATGTGTTTCCT-TCAGCCTCTGCTGTCTGGCCGCTCT
mouse EXON 1 (1) ---------------GATTTCCTCT-AGCCTCTGCTGTCTGATGACACC
dog EXON 1 (1) ---------------------------CCACCTGAGGACTC-TGACTCC
zebrafish EXON 1 (149) TTGGATATTTAGAGCGAT-AGTAATG-GTAGATTCCTACTTAAACTTGG
human EXON 1 (125) GTCTAGGTCCTGGGCCAC-GGGAGAG-CCCCGTCCCTCCTTTCTGAAG-
mouse EXON 1 (33) ATCCAGTACCTGAACATCCAGGAGAGTCCCCATTTCTCCTTTCCAAAG-
dog EXON 1 (23) AACCAGGTCCTGGGCCACCAGGAGAG--CCTGACCCTGTTTTTGGAAG-
zebrafish EXON 1 (196) GCAAAAGTGTAAGCTTATTGAAGACAGCGAGTAGCGCGCGCGCGAGCAT
human CRX (170) -------------------------------------------------
mouse CRX (80) -------------------------------------------------
dog CRX (68) -------------------------------------------------
zebrafish EXON 1 (246) CTACAGCTGTTTGAGGAGCACAGACACGCGCCAGGCGCGAGCACAGACA
human CRX (170) -------------------------------------------------
mouse CRX (80) -------------------------------------------------
dog CRX (68) -------------------------------------------------
zebrafish EXON 1 (296) CGCGACCCCCGACCCGTAAAACAGCGTCGCAGAGAAAAAAGAGAGTGAG
human CRX (170) -------------------------------------------------
mouse CRX (80) -------------------------------------------------
dog CRX (68) -------------------------------------------------
zebrafish EXON 1 (348) AGGGGTGAGAGGGAGGGAGAGAGAGAGCAATAGAGAGAGTGTGCGAGAG
mouse EXON 2 (1) --------------------------------GTGCCCTC--ATCTGGG
human EXON 2 (1) --------------------------------GCCCCCTG--ACTTGGG
dog EXON 2 (1) --------------------------------GCCCGCAGAGACCTGGG
***
zebrafish EXON 1 (398) ACGCGGC-CGTCCCAAGA--ATGATGTCCTACATAAAGC---AGCCCC
mouse EXON 2 (19) CCACAG--TCTCTGAAGATCATGATGGCATATATGAACCCGGGGCCTC
human EXON 2 (21) CCTCAGTGTCCCCGAAGATCATGATGGCGTATATGAACCCGGGGCCCC
dog EXON 2 (23) CCACAGTATCCCCAAAGATCATGATGGCGTATATGAACCCGGGGCCCC
zebrafish EXON 1 (440) ATTATGCTGTGAACGGGTTAACACTGTCCGCCTCAGGAATGGACCTGC
mouse EXON 2 (69) ACTATTCAGTCAATGCCTTGGCTCTGAGTGGCCCCAATGTGGACCTGA
human EXON 2 (71) ACTATTCTGTCAACGCCTTGGCCCTAAGTGGCCCCAGTGTGGATCTGA
dog EXON 2 (73) ACTACTCGGTCAACGCCTTGGCCCTCAGCGGTCCCAGCGTGGATCTGA
zebrafish EXON 1 (490) TCCACACCGCCGTCGGCTACCCAG
mouse EXON 2 (119) TGCACCAGGCTGTCCCATACTCAA
human EXON 2 (121) TGCACCAGGCTGTGCCCTACCCAA
dog EXON 2 (123) TGCACCAAGCTGTGTCCTATCCAA
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