Table 2 of
Vazquez-Chona, Mol Vis 2005;
11:958-970.Table 2 of
Vazquez-Chona, Mol Vis 2005;
11:958-970.
Table 2. Acute phase genes expressed in the injured CNS
Acute phase genes displayed transcript changes in injured retina, brain, and spinal cord. Astrocytic, microglial, and neuronal expressions refer to moderate to high transcript levels in cultured astrocytes [17,20], microglia [18,19], and neurons [20].
Astrocytic Microglial Neuronal Chronic
Symbol Name (alias) expression expression expression expression
-------- ------------------- ---------- ---------- ---------- ----------
Transcription
Atf3 Activating + + - -
transcription
factor 3
Btg2 B-cell + - + -
translocation gene
2
Crem cAMP responsive - - - -
element modulator
Egr1 Early growth + - + -
response 1
(Krox-24/NGFI-A)
Fos FBJ osteosarcoma + + + -
oncogene
Fosl1 Fos-like 1 + - - -
Junb Jun-B oncogene + - + -
Ier3 Immediate early + + + -
response 3 (PRG1)
Nr4a1 Nuclear receptor + - + -
subfamily 4a1
(NGFI-B/nurr7)
Cebpd CCAAT/enhancer + - + +
binding protein
delta
Id2 Inhibitor of DNA + + + +
binding 2 (Idb2)
Irf1 Interferon + + - +
regulatory factor 1
Nfkb1 Nuclear factor + + - +
kappa B p105
Stat3 Signal transducer + - + +
and activator of
transcription 3
Cytokine
Cxcl10 Chemokine (C-X-C + + - +
motif) ligand 10
Il1a Interleukin 1 alpha - + - -
Il1b Interleukin 1, beta - + - +
Scya2 Small inducible - + - -
cytokine A2 (Ccl2)
Scya3 Small inducible + - - -
cytokine A3 (Ccl3)
Cell adhesion/ECM
Cd44 Cd44 antigen + + - +
Icam1 intercellular + + - +
adhesion molecule-1
Plat Plasminogen + + - +
activator tissue
Serpine1 Serine proteinase + - - +
inhibitor-1 (Pai1)
Timp1 Tissue inhibitor of + + - +
metalloproteinase-1
Metabolism
Hmox1 Heme oxygenase + + + +
Mat2a Methionine + - - -
adenosyltransferase
IIa
Ptgs2 Prostaglandin + - - -
synthase 2 (Cox-2)
Other
Ptpn16 Tyrosine + - + -
phosphatase
nonreceptor type
16 (Dusp1/Ptp)
Ifrd1 interferon-related + - + -
developmental
regulator 1
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