Table 3 of
Schmidt, Mol Vis 2005;
11:941-949.Table 3 of
Schmidt, Mol Vis 2005;
11:941-949.
Table 3. Association of smoking and APOE genotypes with AMD
All cases (grade 3-5) and neovascular cases (grade 5) were compared to unrelated controls (grade 1-2) using a logistic regression model containing the variable of interest, adjusted for age and sex. Variables marked with an asterisk were continuous variables that were dichotomized at the median value in the total sample for analysis. The APOE variable was adjusted for ever smoking, age, and sex.
All cases (n=377) versus Neovascular cases (n=260)
controls (n=198) versus controls (n=198)
------------------------ -------------------------
Variable OR (95% CI) p value OR (95% CI) p value
------------------- -------------- ------- --------------- -------
Ever smoking
Yes 2.1 (1.4- 3.2) 0.0007 2.8 (1.7- 4.6) <0.0001
No (ref) 1.0 1.0
Smoking status
Current 5.8 (2.3-14.3) 0.0002 10.9 (4.0-29.2) <0.0001
Past 1.9 (1.2- 2.9) 0.005 2.5 (1.5- 4.1) 0.0008
Never (ref) 1.0 1.0
Years of smoking*
<=Median 33 1.4 (0.8- 2.3) 0.21 1.7 (0.9- 3.0) 0.09
>Median 33 3.6 (2.1- 6.3) <0.0001 5.7 (3.0-10.7) <0.0001
Never (ref) 1.0 1.0
Cigarettes per day*
<=Median 20 2.4 (1.5- 3.9) 0.0005 3.3 (1.9- 5.9) <0.0001
>Median 20 2.6 (1.4- 4.9) 0.0034 3.9 (1.9- 8.2) 0.0002
Never (ref) 1.0 1.0
Pack-years*
<=Median 27.5 1.9 (1.1- 3.3) 0.02 2.4 (1.2- 4.5) 0.009
>Median 27.5 3.2 (1.8- 5.6) <0.0001 5.3 (2.7-10.1) <0.0001
Never (ref) 1.0 1.0
APOE
APOE-2 carrier 1.5 (0.8- 2.8) 0.165 1.7 (0.9- 3.3) 0.105
APOE-4 carrier 0.8 (0.5- 1.3) 0.300 0.8 (0.5- 1.4) 0.451
APOE-3/3 (ref) 1.0 1.0
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