Figure 1 of
Gamundi, Mol Vis 2005;
11:922-928.Figure 1 of
Gamundi, Mol Vis 2005;
11:922-928.
Figure 1. A multiple sequence alignment of fascins
Hyphens indicate gaps of residues inserted by the Clustal analysis program ClustalW. Colors are related to the nature of the residues: red indicates small, hydrophobic, and aromatic amino acids; blue indicates acidic residues; pink denotes basic residues; green denotes hydroxyl, amino, and basic residues; others in gray color. Labels to the right of the sequence numbers denote the amino acid substitutions found in a Spanish population that are shown in purple in the sequence.
Human fascin 1 MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQ 50 Mouse fascin 1 MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQ 50 Xenopus fascin MTSG------PLQLGLVNCNNKYLTAEAFGFKINASASSLKKKQVWSLEP 44 Human retinal fascin MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEP 50 Mutations in human retinal fascin MPTNGLYQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEP 50 H7Y,P5OP Bovine retinal fascin MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQMWVLEP 50 Sea urchin fascin MPAMN----LKYKFGLVNSAGRYLTAEKFGGKVNASGATLKARQVWILEQ 46 Human fascin 1 PPDEAGSAAVCLR-SHLGRYLAADKDGNVTC--EREVPGPDCRFLIVAHD 97 Mouse fascin 1 PPDEAGSAAVCLR-SHLGRYLAADKDGNVTC--EREVPDGDCRFLVVAHD 97 Xenopus fascin AGEDT--SAVLLR-SHLGRFLSADKDGKVSG--ESETAGPECRFLVSAQG 89 Human retinal fascin DPGQG--TAVLLRSSHLGRYLSAEEDGRVAC--EAEQPGRDCRFLVLPQP 96 Mutations in human retinal fascin DPGQG--TAVLLRSSHLGRYLSAEEDGRVAC--EAEQPGRDCRFLVLPQP 96 Bovine retinal fascin DPGEG--TAVLFRSSHLGRYLSAEEDGRVAC--EAERPGRDCRFLVLPQP 96 Sea urchin fascin EESST----ISYLKAPSGNFLSADKNGNVYCSVEDRTEDADTGFEIELQP 92 Human fascin 1 DGRWSLQSEAHRRYFGGTEDRLSCFAQTVS-PAEKWSVHIAMHPQVNIYS 146 Mouse fascin 1 DGRWSLQSEAHRRYFGGTEDRLSCFAQSVS-PAEKWSVHIAMHPQVNIYS 146 Xenopus fascin DGRWALQSEAYGRYFGGSEDRISCFSPSVS-PAEKWGVHLAMHPQFTLYS 138 Human retinal fascin DGRWVLRSEPHGRFFGGTEDQLSCFATAVS-PAELWTVHLAIHPQAHLLS 145 Mutations in human retinal fascin DGRWVLRSEPHGRFFGGTEDQLSCFTTAVF-PAELWTVHLAIYPQAHLLS 145 F111F, A122T, Bovine retinal fascin DGRWVLQSEPHGRFFGGTEDQLSCFATAIT-PAELWTVHLAIHPQAHLLS 145 S126F, H138Y Sea urchin fascin DGKWALKNVSHQRYLACNGEELICSESSTSNPSANWTVQLAIHPQVCMKN 142 Human fascin 1 VTRKRYAHLSARP--ADEIAVDRDVPWGVDSLITLAFQDQ-RYSVQTADH 193 Mouse fascin 1 VTRKRYAHLSARP--ADEIAVDRDVPWGVDSLITLAFQDQ-RYSVQTSDH 193 Xenopus fascin VTRKRYAHLSAN---GDELSVERDVPWGVDSLITLIFQDN-RYSIQTPDH 184 Human retinal fascin VSRRRYVHLCPR---EDEMAADGDKPWGVDALLTLIFRSR-RYCLKSCDS 191 Mutations in human retinal fascin VSRNRYVHLCPR---EDEMAADGDKPWGVDALLTLIFRSR-RYCLKSCDS 191 R149N, Y151Y Bovine retinal fascin VSRRRYAHLCPQ---EDEIAADSNTPWGVDALVTLIFQNR-QYCLKSCDS 191 Sea urchin fascin VQHQRYAHLKTSEEGEDSVVVDELVPWGADSTLTLVYLGKGKYGLEAFNG 192 Human fascin 1 RFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAG 243 Mouse fascin 1 RFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAG 243 Xenopus fascin RLLASDGSLRDGPGPDTGYTLDISSGKVAFRANDGRYLTSSGPSGTMKAG 234 Human retinal fascin RYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAG 241 Mutations in human retinal fascin RYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKTG 241 A240T Bovine retinal fascin RYLRSDGRLVWEPEPRARYTLEFKAGKLAFKDCDGHYLAPVGPAGTLRAG 241 Sea urchin fascin KFVQTDGQLAGTANEQTQFTLIFTSGHLVLRDNNGRHLGVDSGTRVLKSS 242 Human fascin 1 KATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSAN---QDEETD 290 Mouse fascin 1 KATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSAN---QDEETD 290 Xenopus fascin KNSKAGRDELFVLERSCPQVVLTAGNGRNVSTRQGIDLSAN---QDEESD 281 Human retinal fascin RNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSAN---QDDELD 288 Mutations in human retinal fascin RNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSAN---QDDELD 288 P246P Bovine retinal fascin RNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSAN---QDDELD 288 Sea urchin fascin K-PGLTKANYFILEDSCPQGAFEFG-GKYASLKQGEDVSFKLLVDEDIED 290 Human fascin 1 QETFQLEIDRDTKKCA------FRTHTGKYWTLTATGGVQSTASSKNASC 334 Mouse fascin 1 QETFQLEIDRDTRKCA------FRTHTGKYWTLTATGGVQSTASSKNASC 334 Xenopus fascin QETFQLEINKETKMCA------FRTHTGKYWTLSNNGGIQASASTLNNSC 325 Human retinal fascin HETFLMQIDQETKKCT------FYSSTGGYWTLVTHGGIHATATQVSANT 332 K302X, H322H, Mutations in human retinal fascin HETFLMQIDQETKXCT------FYSSTGGYWTLVTHGGIHTTATQVSAHT 332 A323T, N331H Bovine retinal fascin HETFLMQIDQETKKCT------FYSSTGGYWTLVTHGGIQATATQVSENT 332 Sea urchin fascin TETFQLEFVETDKYAIRVCDPKKNSRDAKFWKTVAAGIQANGNSKDQTDC 340 Human fascin 1 YFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRP 384 Mouse fascin 1 YFDIEWCDRRITLRASNGKFVTAKKNGQLAASVETAGDSELFLMKLINRP 384 Xenopus fascin YFDIEWCDRRITLKGANGKFVTSKKNGQLAASVETAGDSELFLMKLINRP 375 Human retinal fascin MFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGKDEEFTLKLINRP 382 Mutations in human retinal fascin MFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDLVGKDEEFTLKLINRP 382 N349N, F367L Bovine retinal fascin MFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGEDEEFTLKLINRP 382 Sea urchin fascin QFSVEYNGNDMHVRAPGGKYVSVRDNGHLFLQDSPKD----FIFRLLNRP 386 Human fascin 1 IIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWT 434 Mouse fascin 1 IIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWT 434 Xenopus fascin LIVFRGEHGFIGCRKMTGTLDSNRSIYDVFELEFNDGAYSLKDSTGKYWT 425 Human retinal fascin ILVLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYRIRGRDGGFWY 432 Mutations in human retinal fascin ILVLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYRIRGRDGGFWY 432 Bovine retinal fascin ILVLRGLDGFVCHRRGSNQLDTNRSVYDVFHLSFSDGAYQIRGRGGGFWH 432 Sea urchin fascin KLVLKCPHGFVGMKEGKAEVACNRSNFDVFTVTYKEGGYTIQDSCGKYWS 436 Human fascin 1 VGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVG--GRYLKGDHAGVLKASA 482 Mouse fascin 1 VGSDSSVTSSSDTPVDFFFEFCDYNKVALKVG--GRYLKGDHAGVLKACA 482 Xenopus fascin VGSDMSVTSSSPTRVDFYFEFCDYNKVAIKVN--GLYLKGDHAGVLKANA 473 Human retinal fascin TGSHGSVCSDGERAEDFVFEFRERGRLAIRARS-GKYLRGGASGLLRADA 481 Mutations in human retinal fascin TGSHGSVCSDGERAEDFVFEFRERGRLAIRARS-GKYLRGGASGLLRADA 481 Bovine retinal fascin TGSHGSVCSDGERAEDFLFEFRERGRLAIRARS-GKYLRGGASGLLRADA 481 Sea urchin fascin CD-DSSRIVLGEAAGTFFFEFHELSKFAIRAESNGMLIKGEQSGLFTANG 485 Human fascin 1 ETVDPASLWEY 493 Mouse fascin 1 ETIDPASLWEY 493 Xenopus fascin ETIDSSTLWEY 484 Human retinal fascin DAPAGTALWEY 492 Mutations in human retinal fascin DAPAGTALWEY 492 Bovine retinal fascin DAPAGVALWEY 492 Sea urchin fascin SEVSKDTLWEF 496 |