Table 2 of
Usui, Mol Vis 2004;
10:832-836.
Table 2. Genes upregulated or downregulated on corneal NV
To identify the genes that are expressed in the process of corneal neovascularization, we compared phosphorescent images of the arrays hybridized with 32P labeled cDNA probes generated from RNA preparations of normal and vascularized corneas. Intensity differences greater than 3 arbitary units between normal and vascularized corneas were accepted as significant and selected for further study. Among the 545 immune related genes tested, 6 genes were upregulated and 1 gene was downregulated in the vascularized corneas compared with normal cornea. In the vascularized corneas, the expression of calreticulin (calregulin), HMGI(Y), apolipoprotein E (apo E), HSP84 (HSP90β), pleiotrophin, and IGFBP-5 were upregulated. In contrast, interferon regulatory factor-1 (IRF-1) was decreased in vascularized corneas compared with normal corneas.
Intensity Accession Gene difference number -------------------------------------- ---------- --------- Upregulated Calregulin (calreticulin) -7.8 M92988 HSP90β (HSP84) -6.17 M36829 HMGI(Y) -4.09 J04179 PTN (pleiotrophin) -3.71 S52357 IGFBP5 -3.69 X81583 Apo-E(Apolipoprotein E) -3.49 M12414 GRP94 (Endoplasmin, GP96) -2.55 J03297 IGFBP6 -2.41 X81584 patched -2.24 U46155 Downregulated Interferon regulatory factor-1 (IRF-1) 5.84 M21065 HSP70 1.95 D85732 Adenosine A2A-R 1.62 Y13346 |