Table 2 of
Usui, Mol Vis 2004;
10:832-836.Table 2 of
Usui, Mol Vis 2004;
10:832-836.
Table 2. Genes upregulated or downregulated on corneal NV
To identify the genes that are expressed in the process of corneal neovascularization, we compared phosphorescent images of the arrays hybridized with 32P labeled cDNA probes generated from RNA preparations of normal and vascularized corneas. Intensity differences greater than 3 arbitary units between normal and vascularized corneas were accepted as significant and selected for further study. Among the 545 immune related genes tested, 6 genes were upregulated and 1 gene was downregulated in the vascularized corneas compared with normal cornea. In the vascularized corneas, the expression of calreticulin (calregulin), HMGI(Y), apolipoprotein E (apo E), HSP84 (HSP90β), pleiotrophin, and IGFBP-5 were upregulated. In contrast, interferon regulatory factor-1 (IRF-1) was decreased in vascularized corneas compared with normal corneas.
Intensity Accession
Gene difference number
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Upregulated
Calregulin (calreticulin) -7.8 M92988
HSP90β (HSP84) -6.17 M36829
HMGI(Y) -4.09 J04179
PTN (pleiotrophin) -3.71 S52357
IGFBP5 -3.69 X81583
Apo-E(Apolipoprotein E) -3.49 M12414
GRP94 (Endoplasmin, GP96) -2.55 J03297
IGFBP6 -2.41 X81584
patched -2.24 U46155
Downregulated
Interferon regulatory factor-1 (IRF-1) 5.84 M21065
HSP70 1.95 D85732
Adenosine A2A-R 1.62 Y13346
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