Figure 1 of
Cassar, Mol Vis 2004;
10:808-813.Figure 1 of
Cassar, Mol Vis 2004;
10:808-813.
Figure 1. Partial protein sequence from three human forms of CNGA3
Variant 1 depicts sequence reported from human cone tissue. The DNA sequence of the novel exon unique to Variant 3 is in blue. DNA sequence of Exon 5, unique to Variant 1, is in orange. DNA sequences of exons 3, 4, and 7 are in red, brown, and purple, respectively.
Variant 1 L S R A H S S S E E T S S V L Q P G I A M E T R G
Variant 2 L S R A H S S S E E T S S V L Q P G I A M E T R G
Variant 3 L S R A H S S S E E T S S V L Q P G I A M E T R G
CTC AGC AGA GCC CAC TCG TCA AGT GAG GAG ACA TCG TCA GTG CTG CAG CCG GGG ATC GCC ATG GAG ACC AGA GGA
Exon 3
Variant 1 L A D S G Q G S F T G Q G I A R
Variant 2 L A D S G Q G S F T G Q G I A R
Variant 3 L A D S G Q G S F T G Q G I A R F G R I Q K K S Q
CTG GCT GAC TCC GGG CAG GGC TCC TTC ACC GGC CAG GGG ATC GCC AGG TTT GGA AGA ATT CAG AAA AAA AGC CAA
Variant 1
Variant 2
Variant 3 P E K V V R A A S R G R P L I G W T Q W C A E D G
CCG GAG AAG GTG GTA AGA GCA GCC AGC CGT GGG AGA CCT TTG ATT GGG TGG ACA CAG TGG TGT GCT GAG GAT GGT
Variant 3 novel exon
Variant 1 L S R L
Variant 2 L S R L
Variant 3 G D E S E M A L A G S P G C S S G P Q G R L S R L
GGT GAT GAG TCT GAA ATG GCT CTG GCA GGG TCT CCC GGG TGC TCG TCT GGA CCC CAG GGC AGG CTG TCG CGC CTC
Variant 1 I F L L R R W A A R H V H H Q D Q G P D S F P D R
Variant 2 I F L L R R W A A R H V H H Q D Q G P D S F P D R
Variant 3 I F L L R R W A A R H V H H Q D Q G P D S F P D R
ATC TTC TTG CTG CGC AGG TGG GCT GCC AGG CAT GTG CAC CAC CAG GAC CAG GGA CCG GAC TCT TTT CCT GAT CGT
Exon 4
Variant 1 F R G A E L K E V S S Q E S N A Q A N V G S Q E P
Variant 2 F R G A E L K E V S S Q E S N A Q A N V G S Q E P
Variant 3 F R G A E L K E V S S Q E S N A Q A N V G S Q E P
TTC CGT GGA GCC GAG CTT AAG GAG GTG TCC AGC CAA GAA AGC AAT GCC CAG GCA AAT GTG GGC AGC CAG GAG CCA
Variant 1 A D R G R S A W P L A K C N T N T S N N T E E E K
Variant 2 A D R G R R K
Variant 3 A D R G R R K
GCA GAC AGA GGG AGA AGC GCC TGG CCC CTG GCC AAA TGC AAC ACT AAC ACC AGC AAC AAC ACG GAG GAG GAG AAG
Exon 5
Variant 1 K T K K K D A I V V D P S S N L Y Y R W L T A I A
Variant 2 K T K K K D A I V V D P S S N L Y Y R W L T A I A
Variant 3 K T K K K D A I V V D P S S N L Y Y R W L T A I A
AAG ACG AAA AAG AAG GAT GCG ATC GTG GTG GAC CCG TCC AGC AAC CTG TAC TAC CGC TGG CTG ACC GCC ATC GCC
Exon 7
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