Table 3 of
White, Mol Vis 2004;
10:738-749.Table 3 of
White, Mol Vis 2004;
10:738-749.
Table 3. Y79 cell PDE enzyme Km values and drug inhibitory effects
Results are shown as mean±standard deviation (n=3). When no inhibition was observed, the entry is shown as "NI". Each particular drug was chosen based on availability and known inhibitory properties.
IC[50] (μM)
--------------------------------------------------
Peak (Substrate) Zaprinast Dipyridamole Vinpocetine Rolipram K[m] (μM)
---------------- --------- ------------ ----------- --------- ----------
1 (cGMP) 2.37±0.25 NI NI NI 2.37±0.53
1 (cAMP) 1.98±0.60 NI NI NI 0.64±0.19
2 (cGMP) 1.69±0.68 NI NI NI 0.70±0.25
2 (cAMP) 1.77±0.14 NI NI NI 0.77±0.029
3 (cAMP) NI NI NI 2.81±0.77 1.25±0.39
|