Table 1 of
White, Mol Vis 2004;
10:738-749.Table 1 of
White, Mol Vis 2004;
10:738-749.
Table 1. PDE inhibitors used in this study
Specificities of some known inhibitors of cyclic nucleotide phosphodiesterase families 1-6. These inhibitors were used to demonstrate which PDE isoforms were present in Y79 cell extracts.
PDE Family Inhibitor (IC[50]) Reference
--------------------------- -------------------------------- ---------
PDE1 Ca[2+]/CaM stimulated Vinpocetine (14 mM) [65]
PDE2 cGMP stimulated Trequinsin (5.4 μM) [66]
EHNA (1 μM) [65]
PDE3 cGMP inhibited cGMP
PDE4 high affinity cAMP Rolipram (0.2-1.0 mM) [65]
specific
PDE5 non-photoreceptor cGMP Zaprinast (130 nM) [65]
specific
PDE6 photoreceptor cGMP Zaprinast (400 nM) [65]
specific dipyridamole (125 nM) [65]
E4021 (1.7 nM) [67]
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