Figure 4 of
Reddy, Mol Vis 2004;
10:696-702.Figure 4 of
Reddy, Mol Vis 2004;
10:696-702.
Figure 4. Conservation of residues across cytochrome P450 families around the region of missense mutations
Multiple sequence alignment of Cytochrome P450 families showing the conservation of wild type amino acids (marked in red) for the 5 novel missense mutations. The human CYP1B1 protein is marked in blue.
P450 species A115P M132R Q144P S239R G466D
---------------------- --------- ------ --------- --------- -----
Human CYP2A7 QAEEFSGRG GYGVAF RAKQLLRFA TSTGQLYEM SIGKR
Human CYP2B6 KAEAFSGRG GYGVIF RWKVLRRFS SVFGQLFEL SLGKR
Human CYP2F1 QGEEFSGRG GNGIAF RWKVLRQFS SPWGELYDI SAGRR
Human CYP2E1 YKDEFSGRG DRGIIF AWKDIRRFS TPWLQLYNN STGKR
Rat CYP1B1 QGGVFADRP GRSLAF RWKERRRAA A--GSLVDV SVGKR
Scup CYP1B1 QGGVFADRP GRSLAF RWKERRRAA A--GSLVDV SVGKR
Human CYP1B1 QGSAFADRP GRSMAF HWKVQRRAA A--GSLVDV SVGKR
Plaice CYP1B QGTDFAGRP GDSLAF WWKVHRRVA A--GSIVDV SLGKR
Scup CYP1C2 HSTEFAGRP GRSMTF QWKMHRKIA A--GSLVDV SSGKR
Monkey CYP1A1 QGDDFKGRP GWSMSF VWAARRRLA S--GNPADF GLGKR
Human CYP1A1 QGDDFKGRP GWSMSF VWAARRRLA S--GNPADF GMGKR
Golden hamster CYP1A1 QGDDFKGRP GKSMIF VWAARRRLA S--GYPPDF GLGKR
Rabbit CYP1A2 QGDDFKGRP GWSMIF VWAARRRLA S--GSPADF GLGKR
Dog CYP1A2 QGDDFKGRP SWSMSF VWAAGRRLA S--GNPLDF GMGKR
Human CYP1A2 QGDDFKGRP GWSLTF VWAARRRLA S--GNPLDF GMGKR
Guinea pig CYP1A2 QSDDFKGRP GWSMIF VWAARRRLA S--GNPVDF GLGKR
Golden hamster CYP1A2 QGDDFKGRP GKSMTF VWAARRRLA S--GNAVDF GLGKR
Chicken CYPA4 QAEDFMGRP GHSLAF AWKARRKLA A--GNPADF GLGKR
Scup CYP1A1 QGDXFAGRP GKSLAF VWRARRKLA S--GNPADF GMGKR
Trout CYP1A1 QGEDFAGRS GKSLAF VWRARRKLA S--GNPADF GMGKR
Oyster toadfish CYP1A1 QGEDFSGRP GKSLAF VWRARRKLA T--GNLADF GLGKR
Human CYP17 KGKDFSGRP NRKGIA HWQLHRRLA K--DSLVDL GAGPR
|