Figure 3. In situ hybridization analysis of Tie-2 during the development of diabetes

A-D: the retinas of STZ induced diabetic rats. E-H: the retinas of saline injected non-diabetic control rats. A,E: 2 weeks after injection. B,F: 1 month after injection, C,G: 3 months after injection. D,H: 6 months after injection. Tie-2 mRNA expression were observed in the GCL and the INL (arrow head). The intensity of Tie-2 mRNA expression was unchanged between diabetic and non-diabetic rats from 2 weeks to 6 months following STZ injection.