Figure 10. Angiostatic effect of trans-filter administered endostatin

Blocking of sprouting from HREC aggregates in collagen after exposure for 5 days to endostatin diffused across the filter from the initial concentration of 10 mg/ml. A: Phase contrast micrographs of triplicates: upper row, non-treated cells; lower row, endostatin treated cells. Original magnifications: x80. B: Quantification of the sprouting in the above experiment.