Figure 4 of
Unsoeld, Mol Vis 2004;
10:468-475.
Figure 4. Chemical structure of MAE 87
The oxoindole core of the substance (framed) competes with ATP for the adenosine-binding pocket of the receptor tyrosine kinase. Thus MAE 87 reduces phosphorylation by the kinase and stops the angiogenesis cascade right at the beginning.