Figure 4 of Unsoeld, Mol Vis 2004; 10:468-475.

Figure 4. Chemical structure of MAE 87

The oxoindole core of the substance (framed) competes with ATP for the adenosine-binding pocket of the receptor tyrosine kinase. Thus MAE 87 reduces phosphorylation by the kinase and stops the angiogenesis cascade right at the beginning.

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Unsoeld, Mol Vis 2004; 10:468-475 <>
©2004 Molecular Vision <>
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