Figure 6 of
Koizumi, Mol Vis 2004;
Figure 6. Cyclic AMP enhances IIR
IIR was enhanced by 8-cpt-cAMP8cptcAMP application. A: Voltage-clamp experiment in the control condition. Voltage steps were from -111 mV to -21 mV, in 10 mV steps, for 200 msec. B: The same voltage-clamp experiment as in panel A, with 8-cpt-cAMP (1 mM) in the extracellular solution. IIR was slightly increased. C: The I-V relationship in the sustained state for panels A and B. Filled circles, control; Open squares, 8-cpt-cAMP. D: Current-clamp experiment in the control condition. Injected currents were from -40 pA to 100 pA, in 20 pA steps, for 200 msec. The input resistance of this cell was calculated as 441 MΩ. E: The same current-clamp experiment as in panel D with 8-cpt-cAMP (1 mM) in the extracellular solution. The input resistance of this cell was decreased slightly to 362 MΩ, and it became difficult to evoke action potentials. At least +140 pA current injection was required to evoke action potentials (data not shown). F: Line plots of all four cells examined.