Figure 5 of
Mukhopadhyay, Mol Vis 2004;
Figure 5. Evolution of "myocilin related" proteins
A proposed evolution of the proteins in the multigene family from the noelin precursor molecule in sub-mammalian species has been shown. The possibility of evolution of myocilin from any of the three noelins has been indicated by dotted lines and arrows, with wider arrow from noelin 2 to suggest it as the most likely immediate precursor molecule.