Figure 4. Cell number following treatment with K-252a, a Trk phosphorylation inhibitor

Adult cell lines were treated with 500 ng/ml K-252a or 500 ng/ml DMSO (vehicle) in 0.5% FBS media for 24 h. Data are reported as a percent of the control; error bars represent the standard deviation of three separate experiments. Three LC cell lines and three ONH astrocyte cell lines were assayed per experiment. Statistically significant differences (Student's t-test) between K-252a and controls are marked with asterisks (*, p<0.01).