Figure 3. Partial alignment of human, mouse and canine ABCA4 amino acid and nucleotide sequences

Alignment of ABCA4 from three species showing the position of missing residues in the dog. Amino acid residue numbers are given above the alignments of both protein (top) and nucleotide (bottom) sequence. Positions absent from non-human species are denoted with (-) and numbered in red type.

               1   1   1   1   1   1         1   1   1        1   1   1   1   1
               2   2   2   2   2   3         3   3   3        3   3   3   3   3
               9   9   9   9   9   0         2   2   2        3   3   3   4   4
               5   6   7   8   9   0         3   4   5        7   8   9   0   1

HumanABCA4    Glu Asn Val Asn Pro Arg       Gly Ala Pro      Pro Glu Cys Pro Gly
MouseABCA4    ... Gln Ala Gly Leu ...       ... --- Gln      ... ... Asp ... ...
CanineABCA4   ... ... --- --- Leu ...       Glu --- ...      ... ... --- Ala Arg

HumanABCA4    GAA AAC GTC AAC CCC CGA       GGG GCG CCG      CCA GAG TGC CCA GGC
MouseABCA4    ... C.A .C. GGT .T. ..G       ..A --- .AA      ... ... GA. ..C ..T
CanineABCA4   ... ... --- --- .T. ...       .A. --- ..A      ... ... --- G.. C..