Figure 3 of
Wang, Mol Vis 2004;
10:103-111.Figure 3 of
Wang, Mol Vis 2004;
10:103-111.
Figure 3. Amino acid sequence of the cytoplasmic domain of human and murine PECAM-1 isoforms.
The amino acid sequence of the cytoplasmic domain of human PECAM-1 isoform lacking exon 14 is compared to the amino acid sequence for human full-length PECAM-1 (A). The amino acid sequence of the cytoplasmic domain of murine PECAM-1 isoforms lacking exon 12, 14, 15, 12&15, 14&15, or 12, 14&15 is compared to the amino acid sequence for murine full-length PECAM-1 (B). The deleted sequences are indicated by hyphens (-). The putative exon sequences of human and murine PECAM-1 were indicated according to the cDNA sequence data (above). The underlined sequences indicate changes in the reading-frame of the amino acid sequence.
A:
Full R K A K A K Q M P V E M S R P A V P L L N S N Δ14 R K A K A K Q M P V E M S R P A V P L L N S N N E K M S D P N M E A N S H Y G H N D D V R N H A M K P I N D N E K M S D P N M E A N S H Y G H N D D V R N H A M K P I N D N K E P L N S D V Q Y T E V Q V S S A E S H K D L G K K D T E N K - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T V Y S E V R K A V P D A V E S R Y S R T E G S L D G T * - - - - - - - - - - - D A V E S R Y S R T E G S L D G T * |
B:
Full R K A K A K Q K P V E M S R P A A P L L N S N Δ12 R K A K A K Q K P V E M S R P A A P L L N S N Δ14 R K A K A K Q K P V E M S R P A A P L L N S N Δ15 R K A K A K Q K P V E M S R P A A P L L N S N Δ12&15 R K A K A K Q K P V E M S R P A A P L L N S N Δ14&15 R K A K A K Q K P V E M S R P A A P L L N S N Δ12,14&15 R K A K A K Q K P V E M S R P A A P L L N S N S E K I S E P S V E A N S H Y G Y D D V S G N D A V K P I N Q S E K I S E P S V E A N S H Y - - - - - - - - - - - - - - - - S E K I S E P S V E A N S H Y G Y D D V S G N D A V K P I N Q S E K I S E P S V E A N S H Y G Y D D V S G N D A V K P I N Q S E K I S E P S V E A N S H Y - - - - - - - - - - - - - - - - S E K I S E P S V E A N S H Y G Y D D V S G N D A V K P I N Q S E K I S E P S V E A N S H Y - - - - - - - - - - - - - - - - N K D P Q N M D V E Y T E V E V S S L E P H Q A L G T R A T E - - D P Q N M D V E Y T E V E V S S L E P H Q A L G T R A T E N K D P Q N M D V E Y T E V E V S S L E P H Q - - - - - - - - N K D P Q N M D V E Y T E V E V S S L E P H Q A L G T R A T E - - D P Q N M D V E Y T E V E V S S L E P H Q A L G T R A T E N K D P Q N M D V E Y T E V E V S S L E P H Q - - - - - - - - - - D P Q N M D V E Y T E V E V S S L E P H Q - - - - - - - - T V Y S E I R K V D P N L M E N R Y S R T E G S L N G T * T V Y S E I R K V D P N L M E N R Y S R T E G S L N G T * - - - - - - - - - - - D L M E N R Y S R T E G S L N G T * T V Y S E I R K V D P - - - - - - - - K N G R L P * T V Y S E I R K V D P - - - - - - - - K N G R L P * - - - - - - - - - - - - - - - - - - - K N G R L P * - - - - - - - - - - - - - - - - - - - K N G R L P * |