Table 3 of
Fischer, Mol Vis 2004;
10:973-986.
Table 3. The combination of insulin and FGF2 stimulates Müller glial expression of filamentous proteins
Similar to acute retinal damage induced by NMDA, the combination of insulin and FGF2 stimulates glial expression of neurofilament, β3 tubulin, and RA4. In contrast, glial expression of neurofilament, β3 tubulin, and RA4 is not induced by insulin or FGF2 alone. Although CNTF induced glial expression of GFAP, this factor has no effect on the expression levels of other filamentous proteins. In the table, treatments are rated as strongly (+++), moderately (++), weakly (+), or not (-) inducing a marker.
Treatment ----------------------------------------- Acute Insulin Marker damage Insulin FGF2 +FGF CNTF ------------- ------ ------- ---- ------- ----- Neurofilament +++ + + +++ - β3 tubulin +++ - - +++ - RA4 +++ - - +++ - GFAP +++ + - - +++ Vimentin + - - ++ - |