Table 4 of
Zhang, Mol Vis 2004;
10:890-900.Table 4 of
Zhang, Mol Vis 2004;
10:890-900.
Table 4. Variation of two point lod scores for myopia at D3S1292 and D3S3637 with penetrance and phenocopy rates
The highest lod score of 3.79 for D3S1292 occurs with 100% penetrance and a 6% phenocopy rate. The "Penet" column indicates the penetrance of the dD and DD genotype (gene carriers). The "Max with lod>3" column indicates the maximum phenocopy rate yielding a lod score (inside brackets) greater than 3 under the different penetrances in each row. The "Max" (bottom of first column) indicates the lowest penetrance yielding a lod score (inside the brackets in the next row down) greater than 3 under the different phenocopy rates in each column. For each combination of penetrance and phenocopy rate, lod scores are given for both markers D3S1292 and D3S3637 as (lod for D3S1292/lod for D3S3637).
Maximum lod score for D3S1292/D3S3637 with phenocopy rate (dd) of
---------------------------------------------------------------------------------------------
Penet 0 0.01 0.05 0.10 0.15 0.20 0.25 Max with lod>3
----- ----------- ----------- ----------- ----------- ----------- ----------- --------- ----------------
1.00 3.69/3.33 3.71/3.34 3.78/3.38 3.73/3.33 3.53/3.13 3.26/2.86 2.92/2.52 0.23 [3.07/2.67]
0.99 3.54/3.39 3.60/3.38 3.72/3.39 3.69/3.33 3.49/3.13 3.22/2.85 2.88/2.50 0.23 [3.03/2.66]
0.95 3.17/3.37 3.30/3.37 3.52/3.38 3.52/3.30 3.34/3.08 3.08/2.80 2.73/2.44 0.21 [3.02/2.03]
0.90 2.89/3.28 3.04/3.30 3.31/3.33 3.33/3.23 3.17/3.00 2.90/2.71 2.55/2.33 0.18 [3.02/2.84]
0.85 2.69/3.18 2.85/3.21 3.13/3.25 3.17/3.14 3.00/2.91 2.73/2.60 2.37/2.21 0.15 [3.00/2.91]
0.80 2.53/3.08 2.68/3.12 2.98/3.17 3.01/3.05 2.84/2.81 2.57/2.49 2.18/2.08 0.11 [2.99/3.10]
0.75 2.39/2.99 2.54/3.03 2.84/3.09 2.87/2.96 2.69/2.70 2.40/2.34 1.99/1.93 0.08 [2.90/3.03]
0.70 2.27/2.90 2.42/2.95 2.72/3.01 2.73/2.86 2.54/2.58 2.23/2.22 1.79/1.76 0.05 [2.72/3.01]
0.65 2.12/2.85 2.30/2.85 2.61/2.93 2.60/2.76 2.39/2.46 2.05/2.07 1.58/1.57 -
0.584 2.02/2.72 2.17/2.77 2.47/2.82 2.44/2.61 2.19/2.28 1.79/1.83 1.27/1.28 -
Max 0.76 0.74 0.70 0.78 0.85 0.93
[2.42/3.01] [2.52/3.02] [2.72/3.01] [2.96/3.02] [3.00/2.91] [3.01/2.77] -
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