Figure 1. Pedigree of the Philippine JOAG family

The asterisk inside certain cells indicates that a DNA sample was available for analysis. The MYOC and OPTN genes were sequenced and, within the image, the "a" indicates the R76K polymorphism, the "b" indicates the -83G->A polymorphism, the "c" indicates the -1000C->G polymorphism, the "d" indicates the T34T polymorphism, the "e" indicates the M98K polymorphism, the "f" indicates the R545Q polymorphism, and the "g" indicates the IVS7+24G->A polymorphism. Square cells refer to males and circle cells refer to females. Cells filled with dark blue are JOAG by history and the cells filled with light blue are JOAG by analysis.