Figure 3. FGFR1 immunoreactivity in monkey fetal and postnatal central retina

FGFR1-IR (red) in fetal and adult macaque retina, double labelled with anti-CRALBP (green; A, B), anti-vimentin (green; C-G) and anti-synaptophsyin (blue; D, G). A: FGFR1-IR is present in axonal bundles in the nerve fiber layer (NFL), on developing pedicles of cone photoreceptors (asterisk) and presumed developing microvilli (dmv) of the retinal pigmented epithelium (RPE). B: FGFR1-IR associated with the developing cone pedicles (asterisk) and on the presumed developing microvilli (dmv). C: Intense FGFR1-IR is present at the level of the developing cone pedicles (asterisk), in the inner segments of cones and associated with in the microvilli (dmv) of the RPE. D: High magnification of the ONL at Fd 120 showing synaptophysin-IR in cones. E: Foveal rim. FGFR1-IR is intense in the GCL and IPL, on cone pedicles (asterisk), inner segments, RPE and to a lesser degree, cone somata. The green labelling in the RPE and at the level of the IS and OS is non-specific. F: A high power view showing FGFR1-IR cone pedicles. G: The same section as F, showing co-localization of FGFR1 protein with synaptophysin on the base of the pedicle. All scale bars represent 20 μm. The cone pedicle (CP), ganglion cell layer (GCL), inner nuclear layer (INL), inner plexiform layer (IPL), inner segment (IS), presumed developing microvilli (dmv), nerve fiber layer (NFL), retinal pigmented epithelium (RPE), ellipsoid (e), external limiting membrane (elm), myoid (m), and nuclei (n) are also identified.