Abstract
The human MAFG gene encodes a basic-leucine zipper (bZIP) protein that belongs to a family of transcription factors related to the v-maf oncogene. The ubiquitously expressed MAFG protein dimerizes with blood cell-specific bZIP factor p45 NF-E2, indicating that it may play a role in regulating hematopoietic gene expression. We have characterized the human MAFG gene and shown that it consists of at least three exons, which are separated by small introns. The first exon is not translated. The genomic structure of the MAFG locus is highly conserved between human and chicken. We have mapped the MAFG gene to human chromosome region 17q25 by fluorescence in situ hybridization. Several putative human disease loci have been mapped to this telomeric portion of chromosome 17.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chickens
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Chromosome Mapping
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Chromosomes, Human, Pair 17 / genetics*
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Cloning, Molecular
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Erythroid-Specific DNA-Binding Factors
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Exons / genetics
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Gene Library
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Humans
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In Situ Hybridization, Fluorescence
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Leucine Zippers / genetics
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MafG Transcription Factor
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Molecular Sequence Data
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NF-E2 Transcription Factor
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NF-E2 Transcription Factor, p45 Subunit
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Repressor Proteins / genetics*
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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Erythroid-Specific DNA-Binding Factors
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MAFG protein, human
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MafG Transcription Factor
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NF-E2 Transcription Factor
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NF-E2 Transcription Factor, p45 Subunit
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NFE2 protein, human
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Repressor Proteins
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Transcription Factors