Abstract
The formation of new blood vessels, angiogenesis, is a tightly regulated process. Extracellular angiogenic inducers stimulate the migration and proliferation of endothelial cells, while negative regulators counteract this effect. Changes in the relative balance of inducers and inhibitors activate the 'angiogenic switch', before stabilizer molecules activate the maturation of nascent blood vessels.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Angiostatins
-
Endothelial Growth Factors / chemistry
-
Endothelial Growth Factors / physiology
-
Endothelium, Vascular / chemistry
-
Endothelium, Vascular / physiology
-
Lymphokines / chemistry
-
Lymphokines / physiology
-
Neovascularization, Physiologic* / physiology
-
Peptide Fragments
-
Plasminogen
-
Protein Sorting Signals
-
Vascular Endothelial Growth Factor A
-
Vascular Endothelial Growth Factors
Substances
-
Endothelial Growth Factors
-
Lymphokines
-
Peptide Fragments
-
Protein Sorting Signals
-
Vascular Endothelial Growth Factor A
-
Vascular Endothelial Growth Factors
-
Angiostatins
-
Plasminogen