Abstract
It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins / biosynthesis*
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Evaluation Studies as Topic
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Gene Expression Regulation, Developmental / physiology*
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Helix-Loop-Helix Motifs
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Molecular Sequence Data
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Promoter Regions, Genetic
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Rats
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Regulatory Sequences, Nucleic Acid*
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Retinal Rod Photoreceptor Cells / cytology
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Retinal Rod Photoreceptor Cells / metabolism*
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Rod Opsins / genetics*
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Transcription Factors / biosynthesis*
Substances
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Ascl1 protein, rat
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Rod Opsins
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Transcription Factors