Abstract
Homeodomain proteins play key roles in development and gene regulation in eukaryotes. Past structural studies have focused on the binding of monomeric homeodomains to DNA, but two recent structures have revealed how homeodomains bind DNA as multimers. The structures of the Drosophila Paired homodimer and the yeast a1/alpha2 heterodimer bound to DNA, along with a high-resolution study of a Drosophila eve-DNA complex, have deepened our understanding of how homeodomains locate their DNA targets.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Bacterial Proteins*
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Base Sequence
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Consensus Sequence
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Drosophila Proteins*
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Drosophila melanogaster / metabolism
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Fungal Proteins / metabolism
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Gene Expression Regulation
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Homeodomain Proteins / chemistry*
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Homeodomain Proteins / metabolism
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Models, Molecular
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Molecular Sequence Data
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Protein Conformation*
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Protein Multimerization
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Repressor Proteins / metabolism
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins*
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Transcription Factors*
Substances
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Bacterial Proteins
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Drosophila Proteins
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Fungal Proteins
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Homeodomain Proteins
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MATA1 protein, S cerevisiae
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MATA2 protein, S cerevisiae
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Repressor Proteins
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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eve protein, Drosophila