Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids

Arch Ophthalmol. 1996 Aug;114(8):933-7. doi: 10.1001/archopht.1996.01100140141005.

Abstract

Objective: To compare the intraocular pressure (IOP) elevating potential of 1.0% rimexolone and 0.1% fluorometholone alcohol ophthalmic suspensions in patients known to have responded to corticosteroids.

Design: In a double-masked, randomized, single-eye, crossover protocol, corticosteroid responsiveness initially was verified in 40 asymptomatic known steroid responders by challenge with either 0.1% dexamethasone sodium phosphate or 1.0% prednisolone acetate for up to 6 weeks. After a 1-month medication washout, subjects randomly received either rimexolone or fluorometholone for 6 weeks. Medications were again discontinued for 1 month, and subjects then received the alternate drug for 6 weeks.

Results: There was no significant difference between rimexolone and fluorometholone in the number of subjects demonstrating a 10-mm Hg increase in IOP or in the mean number of weeks required to achieve a 10-mm Hg response. Responses occurred in significantly more subjects receiving dexamethasone sodium phosphate (P = .001) or prednisolone acetate (P < .001) and in a significantly shorter interval than in subjects receiving rimexolone.

Conclusions: Rimexolone has a low IOP-elevating potential, comparable to that of fluorometholone and less than that of dexamethasone sodium phosphate and prednisolone acetate.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects*
  • Cross-Over Studies
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects*
  • Double-Blind Method
  • Female
  • Fluorometholone / administration & dosage
  • Fluorometholone / adverse effects
  • Humans
  • Intraocular Pressure / drug effects*
  • Male
  • Middle Aged
  • Ocular Hypertension / chemically induced*
  • Ophthalmic Solutions
  • Prednisolone / administration & dosage
  • Prednisolone / adverse effects*
  • Pregnadienes / administration & dosage
  • Pregnadienes / adverse effects*

Substances

  • Anti-Inflammatory Agents
  • Ophthalmic Solutions
  • Pregnadienes
  • Dexamethasone
  • Prednisolone
  • rimexolone
  • Fluorometholone