Abstract
Transforming growth factor beta (TGF-beta) transduces signals through mediation of type I and type II serine/threonine kinase receptors. The expression of TGF-beta type I (T beta R-I) and II (T beta R-II) receptors in rat eyes was investigated immunohistochemically. T beta R-I and T beta R-II immunoreactivity was detected in corneal and conjunctival epithelial cells, corneal endothelial cells, ciliary epithelial cells, lens epithelial cells, retinal pigment epithelial cells, and choroidal vessels. This co-expression of T beta R-I and T beta R-II indicates that the above cells respond to TGF-beta and, because TGF-beta is reported to be produced in ocular tissues, that it may have important autocrine and/or paracrine roles in the growth and metabolism of ocular tissues in situ.
MeSH terms
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Activin Receptors, Type I*
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Animals
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Anterior Eye Segment / chemistry
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Anterior Eye Segment / metabolism
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Choroid / blood supply
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Choroid / chemistry
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Choroid / metabolism
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Ciliary Body / chemistry
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Ciliary Body / cytology
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Ciliary Body / metabolism
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Epithelium / chemistry
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Epithelium / metabolism
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Eye / chemistry
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Eye / metabolism*
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Immunoenzyme Techniques
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Lens, Crystalline / chemistry
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Lens, Crystalline / cytology
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Lens, Crystalline / metabolism
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Male
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Pigment Epithelium of Eye / chemistry
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Pigment Epithelium of Eye / metabolism
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Protein Serine-Threonine Kinases / analysis
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Protein Serine-Threonine Kinases / biosynthesis*
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Rats
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Rats, Inbred Lew
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II
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Receptors, Transforming Growth Factor beta / analysis
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Receptors, Transforming Growth Factor beta / biosynthesis*
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Tissue Distribution
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Transforming Growth Factor beta / biosynthesis*
Substances
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Receptors, Transforming Growth Factor beta
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Transforming Growth Factor beta
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Protein Serine-Threonine Kinases
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Activin Receptors, Type I
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II
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Tgfbr1 protein, rat