Abstract
Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Amino Acid Sequence
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Animals
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Base Sequence
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Betacellulin
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Cell Division / drug effects
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Cells, Cultured
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DNA Replication / drug effects
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Epidermal Growth Factor / pharmacology
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ErbB Receptors / metabolism
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Growth Substances / genetics*
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Growth Substances / isolation & purification
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Growth Substances / pharmacology
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Humans
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Intercellular Signaling Peptides and Proteins*
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Islets of Langerhans / physiopathology
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Kinetics
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Mice
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Molecular Sequence Data
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / drug effects
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Oligodeoxyribonucleotides
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Pancreatic Neoplasms / physiopathology*
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Pigment Epithelium of Eye / cytology
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Pigment Epithelium of Eye / drug effects
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Polymerase Chain Reaction / methods
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Protein Precursors / genetics
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Rats
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Recombinant Proteins / pharmacology
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Sequence Homology, Amino Acid
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Thymidine / metabolism
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Transforming Growth Factor alpha / genetics
Substances
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BTC protein, human
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Betacellulin
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Btc protein, mouse
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Btc protein, rat
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Oligodeoxyribonucleotides
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Protein Precursors
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Recombinant Proteins
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Transforming Growth Factor alpha
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Epidermal Growth Factor
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ErbB Receptors
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Thymidine