Abstract
To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age of Onset
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Aldehyde Reductase / genetics*
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Base Sequence
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China / ethnology
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Cloning, Molecular
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DNA / genetics
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DNA Primers
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DNA, Satellite / genetics
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Diabetes Mellitus / enzymology
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Diabetes Mellitus / genetics*
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Diabetes Mellitus, Type 2 / enzymology
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Diabetes Mellitus, Type 2 / genetics*
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Diabetic Retinopathy / enzymology
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Diabetic Retinopathy / epidemiology
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Diabetic Retinopathy / genetics*
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Female
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Genetic Carrier Screening
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Hong Kong
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Humans
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Introns
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Male
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Middle Aged
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Polymorphism, Genetic*
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Reference Values
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Repetitive Sequences, Nucleic Acid*
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Risk Factors
Substances
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DNA Primers
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DNA, Satellite
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DNA
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Aldehyde Reductase