Abstract
Mouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation. The recent discovery that they recognize non-polymorphic MHC class I like ligands encoded by CD1 family genes sheds a new light on unusual aspects of their development as well as on some of the possible ways in which they might influence the regulation of the T-helper cell (types 1 and 2) classes of immune responses.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD1 / immunology
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Base Sequence
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CD4-Positive T-Lymphocytes / immunology
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Epitopes
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Histocompatibility Antigens Class I / immunology
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / physiology
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Lymphocyte Activation
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Mice / immunology*
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Mice, Inbred Strains
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Mice, Knockout
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Mice, Nude
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Mice, Transgenic
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Models, Immunological
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Molecular Sequence Data
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Phenotype
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Spleen / immunology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / physiology
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Thymus Gland / immunology
Substances
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Antigens, CD1
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Epitopes
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Histocompatibility Antigens Class I
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Receptors, Antigen, T-Cell, alpha-beta