Abstract
Retinal degenerations were produced in albino rats by exposure to constant illumination or in frogs and albino rats by intravitreal injections of ferrous sulfate. Both treatments resulted in the loss of long-chain polyunsaturated fatty acids and the accumulation of lipid hydroperoxides in isolated rod outer segments. We suggest that lipid peroxidation is a factor in certain types of retinal degenerations.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Female
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Ferrous Compounds / toxicity
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Free Radicals
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Light / adverse effects
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Lipid Peroxides / biosynthesis*
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Rana pipiens
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Rats
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Retinal Degeneration / etiology*
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Retinal Degeneration / metabolism
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Rod Cell Outer Segment / drug effects
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Rod Cell Outer Segment / metabolism
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Rod Cell Outer Segment / radiation effects
Substances
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Ferrous Compounds
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Free Radicals
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Lipid Peroxides
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ferrous sulfate