N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

J Med Chem. 1984 Mar;27(3):255-6. doi: 10.1021/jm00369a003.
No abstract available

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Animals
  • Cattle
  • Diabetes Mellitus, Experimental / enzymology
  • Galactitol / metabolism
  • Isoquinolines / pharmacology
  • Lens, Crystalline / enzymology
  • Naphthalenes / pharmacology*
  • Rats
  • Sorbitol / blood
  • Sugar Alcohol Dehydrogenases / antagonists & inhibitors*

Substances

  • Isoquinolines
  • Naphthalenes
  • tolrestat
  • Galactitol
  • Sorbitol
  • alrestatin
  • Sugar Alcohol Dehydrogenases
  • Aldehyde Reductase