Abstract
A polypeptide, which has potent and diverse biological action-including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia-was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.
MeSH terms
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Amino Acids / analysis
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Animals
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Blood Flow Velocity
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Blood Pressure / drug effects
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Blood Vessels / drug effects
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Cardiac Output / drug effects
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Chromatography, Gel
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Chromatography, Ion Exchange
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Countercurrent Distribution
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Gastrointestinal Hormones / isolation & purification
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Gastrointestinal Hormones / pharmacology*
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Glucagon
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Intestine, Small*
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Kinins
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Peptides / analysis
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Peptides / isolation & purification
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Peptides / pharmacology*
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Respiration / drug effects
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Secretin
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Stimulation, Chemical
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Substance P
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Swine
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Vasodilator Agents / pharmacology
Substances
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Amino Acids
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Gastrointestinal Hormones
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Kinins
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Peptides
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Vasodilator Agents
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Secretin
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Substance P
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Glucagon