Polypeptide with broad biological activity: isolation from small intestine

Science. 1970 Sep 18;169(3951):1217-8. doi: 10.1126/science.169.3951.1217.

Abstract

A polypeptide, which has potent and diverse biological action-including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia-was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Blood Flow Velocity
  • Blood Pressure / drug effects
  • Blood Vessels / drug effects
  • Cardiac Output / drug effects
  • Chromatography, Gel
  • Chromatography, Ion Exchange
  • Countercurrent Distribution
  • Gastrointestinal Hormones / isolation & purification
  • Gastrointestinal Hormones / pharmacology*
  • Glucagon
  • Intestine, Small*
  • Kinins
  • Peptides / analysis
  • Peptides / isolation & purification
  • Peptides / pharmacology*
  • Respiration / drug effects
  • Secretin
  • Stimulation, Chemical
  • Substance P
  • Swine
  • Vasodilator Agents / pharmacology

Substances

  • Amino Acids
  • Gastrointestinal Hormones
  • Kinins
  • Peptides
  • Vasodilator Agents
  • Secretin
  • Substance P
  • Glucagon