Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina

Science. 1974 Nov 1;186(4162):449-51. doi: 10.1126/science.186.4162.449.

Abstract

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.

Publication types

  • Comparative Study

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Animals, Newborn / growth & development
  • Animals, Newborn / metabolism
  • Chromatography, Ion Exchange
  • Chromosome Aberrations / metabolism
  • Chromosome Disorders
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism*
  • Mice
  • Mice, Inbred C3H / growth & development
  • Mice, Inbred C3H / metabolism*
  • Mice, Inbred DBA / metabolism
  • Nerve Degeneration*
  • Phosphoric Diester Hydrolases / metabolism
  • Photoreceptor Cells / enzymology
  • Photoreceptor Cells / growth & development
  • Photoreceptor Cells / metabolism*
  • Protein Binding
  • Retina / abnormalities
  • Retina / enzymology
  • Retina / growth & development
  • Retina / innervation
  • Retina / metabolism*
  • Time Factors

Substances

  • Cyclic AMP
  • Phosphoric Diester Hydrolases
  • Adenylyl Cyclases
  • Cyclic GMP