Abstract
We have utilized cDNA probes and in situ hybridization techniques to define the subcellular localization of interphotoreceptor retinoid-binding protein (IRBP) mRNA in bovine and monkey retinas. Results suggest that the mRNA is mainly localized in rod photoreceptor neurons within the outer nuclear layer of the retina. IRBP mRNA is also abundant in cells of the pineal gland, strengthening the analogy between rod photoreceptor cells and pinealocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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DNA
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Eye Proteins*
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Macaca mulatta
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Neurons / metabolism*
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Nucleic Acid Hybridization
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Photoreceptor Cells / metabolism*
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Pineal Gland / metabolism*
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RNA, Messenger / metabolism*
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Retina / cytology
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Retina / metabolism*
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Retinol-Binding Proteins / biosynthesis*
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Retinol-Binding Proteins / genetics
Substances
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Eye Proteins
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RNA, Messenger
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Retinol-Binding Proteins
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interstitial retinol-binding protein
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DNA