Knowledge of the ocular side effects of oral retinoids is important when treating patients with these drugs. The side effects include blepharoconjunctivitis, dry eye syndrome, cutaneous photosensitivity, contact lens intolerance, refractive changes, papilledema and pseudotumor cerebri, corneal opacities, and abnormal retinal function. The signs, symptoms, and management of these ophthalmologic effects are discussed.