A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

Nature. 1990 Jul 19;346(6281):245-50. doi: 10.1038/346245a0.

Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Deletion
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • Female
  • Male
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Nucleic Acid Hybridization
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Sex Determination Analysis*
  • Testis / embryology*
  • Testis / metabolism
  • Y Chromosome*

Substances

  • DNA-Binding Proteins