A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

M H Rosner; M A Vigano; K Ozato; P M Timmons; F Poirier; P W Rigby; L M Staudt

doi:10.1038/345686a0

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

Nature. 1990 Jun 21;345(6277):686-92. doi: 10.1038/345686a0.

Authors

M H Rosner¹, M A Vigano, K Ozato, P M Timmons, F Poirier, P W Rigby, L M Staudt

Affiliation

¹ Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.

PMID: 1972777
DOI: 10.1038/345686a0

Abstract

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Cell Differentiation
DNA-Binding Proteins / genetics*
Down-Regulation
Embryo, Mammalian / metabolism*
Embryo, Nonmammalian*
Endoderm / cytology
Gene Expression*
Genes, Homeobox*
Germ Cells / metabolism*
Mesoderm / cytology
Molecular Sequence Data
Nucleic Acid Hybridization
Octamer Transcription Factor-3
Oocytes / growth & development
Oocytes / metabolism
RNA, Messenger / analysis
RNA, Messenger / genetics
Stem Cells / metabolism*
Transcription Factors / genetics*

Substances

DNA-Binding Proteins
Octamer Transcription Factor-3
RNA, Messenger
Transcription Factors