Abstract
Monoclonal antibodies to human leucocyte antigens, including anti-CD45 and anti-CD68, have been used to describe microglia in flatmounts of normal adult human retina for the first time. Anti-CD45 (the leucocyte common antigen) intensely labeled large numbers of cells in a regular distribution across the retina; anti-CD68 and anti-macrophage antibodies labeled fewer cells with distinctive morphologies, suggesting the presence of subpopulations of microglia in the human retina expressing leucocyte antigens.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antibodies, Monoclonal / metabolism*
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Antigens, CD / metabolism
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Cell Count
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Glial Fibrillary Acidic Protein / metabolism
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HLA Antigens / metabolism*
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Humans
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Immunoenzyme Techniques
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Macrophages / metabolism
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Middle Aged
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Neuroglia / metabolism*
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Retina / metabolism*
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Thiamine Pyrophosphatase / metabolism
Substances
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Antibodies, Monoclonal
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Antigens, CD
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Glial Fibrillary Acidic Protein
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HLA Antigens
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Thiamine Pyrophosphatase