Autophagy: A protective mechanism in response to stress and inflammation

Curr Opin Investig Drugs. 2006 May;7(5):443-50.

Abstract

Autophagy is one of the intracellular systems that is responsible for protein trafficking (degradation/recycling) in eukaryotic cells. This ubiquitous process contributes to cytosolic homeostasis, but its deregulation is often associated with various pathologies, including neurodegenerative diseases and cancer and pathologies with an altered inflammatory response. This review provides an overview of autophagy and discusses its regulation, function and future therapeutic possibilities, with a focus on the role of autophagy in inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy / drug effects
  • Autophagy / physiology*
  • Bacterial Infections / metabolism
  • Bacterial Infections / pathology
  • Homeostasis
  • Humans
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Lysosomes / drug effects
  • Lysosomes / metabolism*
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Kinase Inhibitors / pharmacology
  • Proteins / metabolism*
  • Sirolimus / analogs & derivatives
  • Sirolimus / pharmacology
  • Stress, Physiological / metabolism*
  • Stress, Physiological / pathology
  • Virus Diseases / metabolism
  • Virus Diseases / pathology

Substances

  • Protein Kinase Inhibitors
  • Proteins
  • temsirolimus
  • Proteasome Endopeptidase Complex
  • Sirolimus