Abstract
Postsynaptic release of endocannabinoids can inhibit presynaptic neurotransmitter release on short and long timescales. This retrograde inhibition occurs at both excitatory and inhibitory synapses and may provide a mechanism for synaptic gain control, short-term associative plasticity, reduction of synaptic crosstalk, and metaplasticity.
MeSH terms
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Brain / metabolism*
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Calcium / metabolism
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Cannabinoid Receptor Modulators / metabolism*
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Endocannabinoids*
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Humans
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Neural Inhibition / physiology*
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Neurotransmitter Agents / physiology*
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Signal Transduction / physiology*
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Synapses / metabolism
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Synapses / physiology*
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Synaptic Transmission / physiology*
Substances
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Neurotransmitter Agents
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Calcium