Abstract
Multiple signaling pathways are known to be involved in regulating development of the vertebrate neural retina. Recent publications have demonstrated that Wnt/Frizzled (Fz) signaling components are expressed in the developing retina and may play a fundamental role in retinogenesis. In this review, we summarize Wnt/Fz expression patterns in the developing vertebrate retina, mainly from chick and mouse, and compare them with Wnt/beta-catenin reporter activity. Consistent with the dynamic expression patterns of Wnt pathway components, evidence suggests that Wnt/Fz signaling has multiple roles during retinal development.
Copyright 2004 S. Karger AG, Basel.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation / physiology
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism
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Frizzled Receptors
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Gene Expression Regulation, Developmental / physiology
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism*
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Receptors, G-Protein-Coupled
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Receptors, Neurotransmitter / genetics
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Receptors, Neurotransmitter / metabolism*
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Retina / embryology*
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Retina / physiology
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Signal Transduction / physiology*
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Vertebrates / embryology*
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Vertebrates / physiology
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Wnt Proteins
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beta Catenin
Substances
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CTNNB1 protein, human
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Cytoskeletal Proteins
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Frizzled Receptors
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Fzd1 protein, mouse
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Intercellular Signaling Peptides and Proteins
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Receptors, G-Protein-Coupled
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Receptors, Neurotransmitter
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Trans-Activators
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Wnt Proteins
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beta Catenin