Systemic T-cell activation in acute clinically isolated optic neuritis

Hanne Roed; Jette Frederiksen; Annika Langkilde; Torben Lykke Sørensen; Martin Lauritzen; Finn Sellebjerg

doi:10.1016/j.jneuroim.2005.02.002

Systemic T-cell activation in acute clinically isolated optic neuritis

J Neuroimmunol. 2005 May;162(1-2):165-72. doi: 10.1016/j.jneuroim.2005.02.002.

Authors

Hanne Roed¹, Jette Frederiksen, Annika Langkilde, Torben Lykke Sørensen, Martin Lauritzen, Finn Sellebjerg

Affiliation

¹ The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK-2600 Glostrup, Denmark. roeden@dadlnet.dk

PMID: 15833372
DOI: 10.1016/j.jneuroim.2005.02.002

Abstract

We examined untreated 60 patients with acute monosymptomatic optic neuritis (ON). Patients examined early after onset showed increased expression of HLA-DR and CD45R0 on CD4 and CD8 T cells. Expression of HLA-DR on CD4 T cells was higher in patients without IgG oligoclonal bands. Expression of HLA-DR on CD4 and CD8 T cells correlated negatively with measures of disease activity and positively with measures of good visual function, and expression of CD45R0 on CD4 T cells correlated negatively with measures of disease activity. We hypothesize that HLA-DR expression may characterize a protective T-cell subset in ON.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adolescent
Adult
CD4-Positive T-Lymphocytes / physiology*
CD8-Positive T-Lymphocytes / physiology*
Evoked Potentials, Visual / physiology
Female
Flow Cytometry / methods
Gene Expression Regulation / physiology
HLA-DR Antigens / blood
HLA-DR Antigens / cerebrospinal fluid
Humans
Leukocyte Common Antigens / blood
Leukocyte Common Antigens / cerebrospinal fluid
Lymphocyte Activation / physiology*
Male
Middle Aged
Optic Neuritis / blood
Optic Neuritis / cerebrospinal fluid
Optic Neuritis / pathology*
Optic Neuritis / physiopathology
Vision, Ocular / physiology

Substances

HLA-DR Antigens
Leukocyte Common Antigens