Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Corneal Transplantation / immunology*
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Dendritic Cells / immunology
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Flow Cytometry
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Gene Expression Regulation / immunology*
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Glycoproteins
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Graft Rejection / immunology
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Humans
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Hypersensitivity, Delayed / immunology*
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Keratitis / immunology*
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Lymphangiogenesis / immunology*
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Membrane Transport Proteins
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Mice
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Microscopy, Fluorescence
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Models, Animal
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Signal Transduction / immunology*
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Vascular Endothelial Growth Factor C / metabolism
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Vascular Endothelial Growth Factor Receptor-3 / antagonists & inhibitors*
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Vascular Endothelial Growth Factor Receptor-3 / metabolism
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Vesicular Transport Proteins
Substances
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Glycoproteins
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LYVE1 protein, human
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Membrane Transport Proteins
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Vascular Endothelial Growth Factor C
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Vesicular Transport Proteins
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Xlkd1 protein, mouse
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Vascular Endothelial Growth Factor Receptor-3