Abstract
The vertebrate nervous system contains an immense diversity of distinct cellular components that are organized into precise spatial patterns. The importance of accurate neuronal architecture is particularly obvious in the retina, where it is necessary for the formation of visual images. The retina is structured in a distinct layered pattern that is remarkably conserved in evolution, including phyla as diverse as primates and teleost fish. Genetic analysis in zebrafish reveals mechanisms that are essential for the formation of this architecture.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation / genetics
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Cell Differentiation / physiology
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Central Nervous System / cytology
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Central Nervous System / embryology
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Central Nervous System / metabolism
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Embryo, Nonmammalian / cytology
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Embryo, Nonmammalian / embryology
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Embryo, Nonmammalian / metabolism
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Eye / anatomy & histology
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Eye / cytology
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Eye / embryology
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Gene Expression Regulation, Developmental
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Hedgehog Proteins
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Isoenzymes
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Models, Biological
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Mutation
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Neurons / cytology
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Neurons / physiology
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Protein Kinase C / physiology
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Retina / anatomy & histology
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Retina / cytology
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Retina / embryology*
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Trans-Activators / physiology
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Zebrafish / embryology*
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Zebrafish / genetics
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Zebrafish / physiology
Substances
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Hedgehog Proteins
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Isoenzymes
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Trans-Activators
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Protein Kinase C
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protein kinase C lambda