Intracellular cargo delivery using tat peptide and derivatives

Med Res Rev. 2004 Jan;24(1):1-12. doi: 10.1002/med.10056.

Abstract

Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV-1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport, Active / physiology
  • Cell Membrane / metabolism
  • Cell Membrane Permeability
  • Drug Delivery Systems
  • Gene Products, tat / metabolism*
  • Humans
  • Nucleic Acids / metabolism
  • Peptide Fragments / metabolism*
  • Protein Transport / physiology*
  • tat Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, tat
  • Nucleic Acids
  • Peptide Fragments
  • tat Gene Products, Human Immunodeficiency Virus
  • tat peptide (48-60), Human immunodeficiency virus 1