Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism

Br J Pharmacol. 1992 Jun;106(2):231-2. doi: 10.1111/j.1476-5381.1992.tb14321.x.

Abstract

Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108-15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the omega-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology
  • Calcium Channel Blockers / pharmacology*
  • Cannabinoids / pharmacology*
  • Cyclohexanols / pharmacology
  • Dronabinol / pharmacology
  • GTP-Binding Proteins / metabolism
  • Humans
  • Neuroblastoma / metabolism*
  • Peptides, Cyclic / pharmacology
  • Pertussis Toxin*
  • Receptors, Cannabinoid
  • Receptors, Drug / drug effects*
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / metabolism
  • Virulence Factors, Bordetella / pharmacology*
  • omega-Conotoxins*

Substances

  • Analgesics
  • Calcium Channel Blockers
  • Cannabinoids
  • Cyclohexanols
  • Peptides, Cyclic
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Virulence Factors, Bordetella
  • omega-Conotoxins
  • Conus magus toxin
  • Dronabinol
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
  • Pertussis Toxin
  • GTP-Binding Proteins