Abstract
Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.
MeSH terms
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Animals
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Diabetic Retinopathy / etiology*
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Diabetic Retinopathy / pathology
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Diabetic Retinopathy / physiopathology
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Humans
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Insulin / physiology*
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Insulin-Like Growth Factor I / physiology
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Mice
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Models, Biological
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Neovascularization, Pathologic
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Receptor, IGF Type 1 / physiology
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Receptor, Insulin / physiology
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Retinal Vessels / pathology
Substances
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Insulin
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Insulin-Like Growth Factor I
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Receptor, IGF Type 1
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Receptor, Insulin